3. Advances in Antituberculosis Drugs
نویسندگان
چکیده
منابع مشابه
Antituberculosis drugs and hepatotoxicity.
Isoniazid, pyrazinamide and rifampicin have hepatotoxic potential, and can lead to such reactions during antituberculosis chemotherapy. Most of the hepatotoxic reactions are dose-related; some are, however, caused by drug hypersensitivity. The immunogenetics of antituberculosis drug-induced hepatotoxicity, especially inclusive of acetylaor phenotype polymorphism, have been increasingly unravell...
متن کاملStability of antituberculosis drugs mixed in food.
5. Mandell DL, Wald ER, Michaels MG, Dohar JE. Management of nontuberculous mycobacterial cervical lymphadenitis. Arch Otolaryngol Head Neck Surg 2003; 129:341–4. 6. Gerrits JA, Wolfs TF, Geelen SP. Three toddlers with a swelling in the neck [in Dutch]. Ned Tijdschr Geneeskd 2003; 147:225–9. 7. Lindeboom JA, Kuijper EJ, Bruijnesteijn van Coppenraet ES, R. Lindeboom, Prins JM. Surgical excision ...
متن کاملThe early bactericidal activity of antituberculosis drugs.
Early bactericidal activity studies measure the ability of antituberculosis treatments to reduce the burden of Mycobacterium tuberculosis in sputum specimens collected overnight from smear-positive pulmonary tuberculosis patients during the first 14 days of therapy. This confirms the efficacy of novel agents or drug combinations in human patients, allows comparison of different drug dosages and...
متن کاملEvaluation of new antituberculosis drugs in mouse models.
In the study of the activity of PA-824 in mice performed by Nuermberger et al. (3), the authors observe that “regimens were not statistically different on the primary outcome” and propose that new studies using shorter regimens are needed “to determine conclusively whether substitution of PA-824 for isoniazid has the potential” to shorten treatment in humans. We agree but have concerns about th...
متن کاملAdverse effects of oral second-line antituberculosis drugs in children.
INTRODUCTION Increasing numbers of children with drug-resistant tuberculosis are accessing second-line antituberculosis drugs; these are more toxic than first-line drugs. Little is known about the safety of new antituberculosis drugs in children. Knowledge of adverse effects, and how to assess and manage these, is important to ensure good adherence and treatment outcomes. AREAS COVERED A Pubm...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 2013
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.102.2922